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KMID : 0438219780150030239
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Korea University Medical Journal
1978 Volume.15 No. 3 p.239 ~ p.265
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Experimental Studies on Changes Following Various Type of Portacaval Shunt Operations
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Abstract
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In experimental study for portal decompression, the author performed three kinds of portacaval shunts; side-to-side portacaval shunt, 5 H-type portacaval shunt, and 5 end to-side . portacaval shunt, 5 in experimental adults dogs.
The experimental dogs were observed pre and post operatively and changes of body weight, liver function test, blood ammonia lever were tested until 6 weeks after surgery and altzheimer cell were studied after autopsy at the 6th post operative week.
The significant changes. are as follows;
L In the side-to-side and end-to-side portacaval shunt groups, the body weight was decreased temporarily, but in the H-type portacaval shunt group, change of body weight was not observed.
The total serum protein was decreased after the 3rd post operative week in all three. kinds of portacaval shunts, `the serum albumin -lever was decreased in the early post operative week, but it was returned to pre operative status during= later post operative weeks.
The serum globulin level was increased: after Zntire post operative period. The serum cholesterol level was decreased at all post operative periods in types of portacaval shunts.
f In the serum alkaline phosphatase´tests, there were no significant changes in the end-to-side and H-type portacaval shunt groups at all post operative periods.. But in the side-to-side portacaval shunt groups, the serum alkaline phosphatase level was increased markedly at the fourth post -operative % week. ,
The S. G. 0. T. , S-G. P:-´T, and serum bililubin were not significantly changed in- the´ post operative periods.
3. In the -H-type and end-tcside portacaval ´shunt groups, the ablood ammonia `levelwas not´ hanged´
r ignilicanti riduring expenmental-periodslit!16;howed ´rogfi~esibe-?ncrease ins the´ ´o d ati :.
period in the side-to-side portacaval shunt group.
The highest level of blood ammonia was in the 6th post operative week in the side-to-side portacaval shunt. At that time, its level was increased 124.14% more than that of pre operative period.
4. The most significant increment of the Altzheimer cell was observed in the side-t o-side portacaval shunt group, the second highest increment of Altzheimer cells was seen in the H-type of portacaval shunt, the least increment was in theend-to-side type of portacaval shunt.
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